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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CFTR All Species: 29.7
Human Site: Y1073 Identified Species: 59.39
UniProt: P13569 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P13569 NP_000483.3 1480 168142 Y1073 R A F G R Q P Y F E T L F H K
Chimpanzee Pan troglodytes Q2QLE5 1480 168220 Y1073 R A F G R Q P Y F E T L F H K
Rhesus Macaque Macaca mulatta NP_001028110 1481 168436 Y1073 R A F G R Q P Y F E T L F H K
Dog Lupus familis XP_542642 1516 170242 R1113 R A Y K A E E R F Q E L F D A
Cat Felis silvestris
Mouse Mus musculus P26361 1476 167852 Y1068 R A F R R Q T Y F E T L F H K
Rat Rattus norvegicus P34158 1476 167812 Y1068 R A F R R Q T Y F E T L F H K
Wallaby Macropus eugenll
Platypus Ornith. anatinus Q07DZ6 1484 168832 Y1077 R A F G R Q T Y F E A L F H K
Chicken Gallus gallus Q5F364 1525 170953 H1043 I F A S R H L H L D L L H N V
Frog Xenopus laevis P26363 1485 168877 Y1078 R A F G R Q P Y F E T L F H K
Zebra Danio Brachydanio rerio NP_001038348 1485 168381 F1076 G L W T I R A F E R Q A Y F E
Tiger Blowfish Takifugu rubipres NP_001041505 1511 170002 Y1105 R A F G R Q T Y F E T L F H K
Fruit Fly Dros. melanogaster P91660 1290 143990 A911 T T I R A L D A Q R V L E K E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.1 23.6 N.A. 78.5 78 N.A. 83.3 20.6 77.3 55.7 58.7 28.3 N.A. N.A. N.A.
Protein Similarity: 100 99.8 98.9 44.2 N.A. 88.7 88.1 N.A. 92.3 41.3 88.3 75.5 76.4 50.4 N.A. N.A. N.A.
P-Site Identity: 100 100 100 33.3 N.A. 86.6 86.6 N.A. 86.6 13.3 100 0 93.3 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 53.3 N.A. 86.6 86.6 N.A. 86.6 33.3 100 33.3 93.3 13.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 75 9 0 17 0 9 9 0 0 9 9 0 0 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 9 0 0 9 0 0 0 9 0 % D
% Glu: 0 0 0 0 0 9 9 0 9 67 9 0 9 0 17 % E
% Phe: 0 9 67 0 0 0 0 9 75 0 0 0 75 9 0 % F
% Gly: 9 0 0 50 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 9 0 9 0 0 0 0 9 67 0 % H
% Ile: 9 0 9 0 9 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 9 0 0 0 0 0 0 0 0 0 9 67 % K
% Leu: 0 9 0 0 0 9 9 0 9 0 9 92 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % N
% Pro: 0 0 0 0 0 0 34 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 67 0 0 9 9 9 0 0 0 0 % Q
% Arg: 75 0 0 25 75 9 0 9 0 17 0 0 0 0 0 % R
% Ser: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 9 9 0 9 0 0 34 0 0 0 59 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 9 % V
% Trp: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 9 0 0 0 0 67 0 0 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _